ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

Base Information

Chemical Name:ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate
CAS No.:1335466-01-7
Molecular Formula:C₂₁H₁₇Cl₂N₃O₅
Molecular Weight:462.289
Hs Code.:

Synonyms:ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

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Chemical Property of ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

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Technology Process of ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

There total 9 articles about ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1335465-94-5
ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate

: 1335466-01-7
ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 60 ℃; under 750.075 Torr;
DOI:10.1002/jlcr.1901

Reference yield:

: 103855-01-2
ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate

: 1335466-01-7
ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: polyphosphoric acid / 0.17 h / 70 - 130 °C

2.1: trichlorophosphate / 20 °C / Inert atmosphere

2.2: 8 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 0.17 h / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 1.5 h / Inert atmosphere

5.1: dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: sodium ethanolate / ethanol / 1 h / 20 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / methanol / 60 °C / 750.08 Torr

With palladium 10% on activated carbon; hydrogen; sodium ethanolate; sodium tris(acetoxy)borohydride; triethylamine; trichlorophosphate; In methanol; ethanol; dichloromethane; 1.1: Fischer indole synthesis / 2.2: Vilsmeier formylation;
DOI:10.1002/jlcr.1901

Reference yield:

: 6373-46-2
p-benzyloxyaniline

: 1335466-01-7
ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

3: sodium ethanolate / ethanol / 1 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 60 °C / 750.08 Torr

With palladium 10% on activated carbon; hydrogen; sodium ethanolate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane;
DOI:10.1002/jlcr.1901