2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile

Base Information

• Chemical Name: 2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile
• CAS No.: 1373349-70-2
• Molecular Formula: C₂₀H₁₄ClN₃O
• Molecular Weight: 347.804

Synonyms:2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile

Chemical Property of 2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile

Chemical Property:

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Technology Process of 2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile

There total 1 articles about 2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-methyl-8-quinolinol (826-81-3) + 4-chlorobenzylidenemalonodinitrile (1867-38-5) → 2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile (1373349-70-2)

Guidance literature:

With piperidine; In ethanol; for 1h; Reflux;

DOI:10.3998/ark.5550190.0012.b12

Reference yield: 83.0%

2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile (1373349-70-2) + acetic anhydride (108-24-7) → 2-acetylamino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile (1384215-00-2)

Guidance literature:

for 0.5h; Reflux;

DOI:10.1007/s00044-012-0142-7

Reference yield: 82.0%

2-amino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile (1373349-70-2) + orthoformic acid triethyl ester (122-51-0) → 4-(4-chlorophenyl)-2-ethoxymethyleneamino-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile (1384215-14-8)

Guidance literature:

In acetic anhydride; for 3h; Reflux;

DOI:10.1007/s00044-012-0142-7

upstream raw materials:

2-methyl-8-quinolinol

4-chlorobenzylidenemalonodinitrile

Downstream raw materials:

2-(aminomethyleneamino)-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile

8-amino-7-(4-chlorophenyl)-2-methyl-7H-pyrimido[4',5':6,5]pyrano[3,2-h]quinoline

2-acetylamino-4-(4-chlorophenyl)-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile

4-(4-chlorophenyl)-2-ethoxymethyleneamino-9-methyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile

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