(-)-N-benzylnormorphine

Base Information

• Chemical Name: (-)-N-benzylnormorphine
• CAS No.: 114720-71-7
• Molecular Formula: C₂₃H₂₃NO₃
• Molecular Weight: 361.441
• Mol file: 114720-71-7.mol

Synonyms:(-)-N-benzylnormorphine

Chemical Property of (-)-N-benzylnormorphine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (-)-N-benzylnormorphine

There total 5 articles about (-)-N-benzylnormorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-benzylnorcodeine (130727-24-1) → (-)-N-benzylnormorphine (114720-71-7)

Guidance literature:

With boron tribromide; In dichloromethane; at -10 ℃; for 1.25h;

DOI:10.1021/jm960188q

Reference yield:

normorphine (466-97-7,13396-02-6,99295-16-6,142864-36-6) → (-)-N-benzylnormorphine (114720-71-7)

Guidance literature:

With sodium hydrogencarbonate; In ethanol;

DOI:10.1021/jm00311a014

Reference yield:

benzyl bromide (100-39-0) → (-)-N-benzylnormorphine (114720-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K₂CO₃ / 1.) DMF, RT, 5 min, 2.) DMF, RT, 2.5 h

2: 70 percent / BBr₃ / CH₂Cl₂ / 1.25 h / -10 °C

With boron tribromide; potassium carbonate; In dichloromethane;

DOI:10.1021/jm960188q

upstream raw materials:

N-benzylnorcodeine

normorphine

benzyl bromide

norcodeine

Downstream raw materials:

Trifluoro-methanesulfonic acid (R)-6-benzyl-11-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-yl ester

(-)-N-benzyl-3-deoxy-3-methylnormorphine