N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide

Base Information

Chemical Name:N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide
CAS No.:432504-37-5
Molecular Formula:C₃₅H₄₄NO₂PSi
Molecular Weight:569.799
Hs Code.:

Synonyms:N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide

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Technology Process of N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide

There total 4 articles about N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 432504-36-4
N,N-disopropyl-8-[tert-butyl(dimethyl)silyloxy]-1-naphthamide

: 432504-37-5
N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide

Guidance literature:: N,N-disopropyl-8-[tert-butyl(dimethyl)silyloxy]-1-naphthamide; With sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

chloro-diphenylphosphine; In tetrahydrofuran; at -78 ℃; for 4h;
DOI:10.1021/ol0258233

Reference yield:

: 252270-69-2
N,N-diisopropyl-8-hydroxy-1-naphthamide

: 432504-37-5
N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / imidazole / dimethylformamide / 20 h / 45 °C

2.1: s-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 87 percent / tetrahydrofuran; hexane / 4 h / -78 °C

With 1H-imidazole; sec.-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol0258233

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 432504-37-5
N,N-diisopropyl-8-(tert-butyldimethylsilyloxy)-2-diphenylphosphino-1-naphthamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / imidazole / dimethylformamide / 20 h / 45 °C

2.1: s-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 87 percent / tetrahydrofuran; hexane / 4 h / -78 °C

With 1H-imidazole; sec.-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol0258233