3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

Base Information

• Chemical Name: 3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine
• CAS No.: 100856-25-5
• Molecular Formula: C₁₈H₁₈N₂O₃
• Molecular Weight: 310.353
• Mol file: 100856-25-5.mol

Synonyms:3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

Chemical Property of 3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

There total 4 articles about 3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{[Methyl-(5-methyl-2-phenyl-1H-pyrrol-3-yl)-amino]-methylene}-malonic acid diethyl ester → 3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine (100856-25-5)

Guidance literature:

With polyphosphoric ester; at 100 - 110 ℃; for 2h; Yield given;

DOI:10.1002/jhet.5570220323

Reference yield:

N-<2-phenyl-5-methylpyrrol-3-yl>aminomethylenemalonic acid, diethyl ester (100856-21-1) → 3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine (100856-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 1.) reflux, 2 hrs, 2.) r.t., overnight

2: polyphosphoric ester / 2 h / 100 - 110 °C

With polyphosphoric ester; sodium hydride; In tetrahydrofuran;

DOI:10.1002/jhet.5570220323

Reference yield:

2-phenyl-3-amino-5-methylpyrrole hydrochloride (100856-20-0) → 3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine (100856-25-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / ethanol / 2 h / Ambient temperature

2: sodium hydride / tetrahydrofuran / 1.) reflux, 2 hrs, 2.) r.t., overnight

3: polyphosphoric ester / 2 h / 100 - 110 °C

With polyphosphoric ester; sodium methylate; sodium hydride; In tetrahydrofuran; ethanol;

DOI:10.1002/jhet.5570220323

upstream raw materials:

N-<2-phenyl-5-methylpyrrol-3-yl>aminomethylenemalonic acid, diethyl ester

2-phenyl-3-amino-5-methylpyrrole hydrochloride

2-phenyl-3-amino-4-t-butoxycarbonyl-5-methylpyrrole hydrochloride

Downstream raw materials:

6-Benzyl-1,5-dimethyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

6-Allyl-1,5-dimethyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine-3-carboxylic acid

3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine