N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide

Base Information

Chemical Name:N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide
CAS No.:200400-39-1
Molecular Formula:C₂₄H₂₉N₃O₅
Molecular Weight:439.511
Hs Code.:

<i>N</i>-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide

Synonyms:N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide

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Chemical Property of N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide

Chemical Property:

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Technology Process of N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide

There total 10 articles about N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 200400-36-8
4-(3-pyridylcarbonyl)benzoic acid

: 200400-22-2
2-amino-N-(2-cyclohexyloxy-ethyl)-3-hydroxy-propionamide

: 200400-39-1
N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6.5h; Yield given;
DOI:10.1021/jm980173n

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 200400-39-1
N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) Et₂O, hexane, -78 deg C, 25 min, 2.) Et₂O, hexane, a) -78 deg C, 2 h, b) RT, 2 h

2: 81 percent / MnO₂ / tetrahydrofuran / 17 h / 70 °C

3: 1.0N aq. NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

4: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

With 4-methyl-morpholine; manganese(IV) oxide; sodium hydroxide; n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980173n

Reference yield:

: 1817-88-5
2-Cyclohexyloxyethanol

: 200400-39-1
N-[1-(2-cyclohexyloxy-ethylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / dimethylformamide / 1 h / 0 °C

2: NaN₃ / dimethylformamide; H₂O / 60 - 70 °C

3: H₂O, Ph₃P / tetrahydrofuran / Ambient temperature

4: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

5: TFA / CH₂Cl₂ / 0 - 20 °C

6: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

With 4-methyl-morpholine; sodium azide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980173n