7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine

Base Information

• Chemical Name: 7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine
• CAS No.: 357442-19-4
• Molecular Formula: C₃₄H₃₀N₆O₄S
• Molecular Weight: 618.716

Synonyms:7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine

Chemical Property of 7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine

Chemical Property:

Purity/Quality:

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Technology Process of 7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine

There total 2 articles about 7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

tri(1H-1,2,4-triazol-1-yl)phosphine oxide (72741-18-5) + 3-(2,3-O-Isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one (150966-40-8) → 7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine (357442-19-4)

Guidance literature:

In pyridine; at 20 ℃; for 24h;

DOI:10.1081/NCN-100002083

Reference yield:

1,2,4-Triazole (288-88-0) + 3-(2,3-O-Isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one (150966-40-8) → 7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine (357442-19-4)

Guidance literature:

With pyridine; trichlorophosphate; at 25 ℃; for 8h;

DOI:10.1021/jo00086a054

Reference yield: 76.0%

7-(1,2,4-triazol-1-yl)-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine (357442-19-4) + ethanethiol (75-08-1) → 7-ethylthio-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 25 ℃; for 6h;

DOI:10.1081/NCN-100002083

upstream raw materials:

1,2,4-Triazole

3-(2,3-O-Isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one

tri(1H-1,2,4-triazol-1-yl)phosphine oxide

Downstream raw materials:

7-Amino-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-isothiazolo<4,5-d>pyrimidine

7-isopropylidenehydrazino-3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)isothiazolo[4,5-d]pyrimidine

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