2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

Base Information

• Chemical Name: 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone
• CAS No.: 127431-10-1
• Molecular Formula: C₂₁H₂₄N₂O₅
• Molecular Weight: 384.432
• Mol file: 127431-10-1.mol

Synonyms:2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

Chemical Property of 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

There total 6 articles about 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone (202843-56-9) + N-Benzoylpiperazine (13754-38-6) → 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone (127431-10-1)

Guidance literature:

With potassium carbonate; In dichloromethane; at 40 ℃; for 2h;

DOI:10.3184/174751911X13099411630089

Reference yield:

1-(chloromethyl)-2,3,4,5-tetramethoxy-6-methylbenzene (127430-84-6) → 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone (127431-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / water; tetrahydrofuran / 2 h / 0 - 25 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With ammonium cerium (IV) nitrate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.09.042

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone (127431-10-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 2 h / 70 °C

1.2: 2 h / 150 °C

2.1: dihydrogen peroxide; sodium bromide; acetic acid / 1 h / 40 °C

3.1: sodium methylate; copper(l) chloride; N,N-dimethyl-formamide / 4 h / 100 °C

4.1: hydrogen bromide / 1 h / 40 °C

5.1: ammonium cerium (IV) nitrate / water; tetrahydrofuran / 2 h / 0 - 20 °C

6.1: potassium carbonate / dichloromethane / 0.5 h / 40 °C / Green chemistry

With ammonium cerium (IV) nitrate; hydrogen bromide; dihydrogen peroxide; sodium methylate; potassium carbonate; hydrazine hydrate; acetic acid; N,N-dimethyl-formamide; sodium bromide; copper(l) chloride; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; ethylene glycol; 1.1: |Wolff-Kishner Reduction;

DOI:10.1016/j.bioorg.2016.08.008

upstream raw materials:

2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

N-Benzoylpiperazine

1-(chloromethyl)-2,3,4,5-tetramethoxy-6-methylbenzene

3,4,5-trimethoxy-benzaldehyde