2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

Base Information

Chemical Name:2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone
CAS No.:127431-10-1
Molecular Formula:C₂₁H₂₄N₂O₅
Molecular Weight:384.432
Hs Code.:

Synonyms:2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

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Chemical Property of 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

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Technology Process of 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

There total 6 articles about 2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 202843-56-9
2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

: 13754-38-6
N-Benzoylpiperazine

: 127431-10-1
2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

Guidance literature:: With potassium carbonate; In dichloromethane; at 40 ℃; for 2h;
DOI:10.3184/174751911X13099411630089

Reference yield:

: 127430-84-6
1-(chloromethyl)-2,3,4,5-tetramethoxy-6-methylbenzene

: 127431-10-1
2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / water; tetrahydrofuran / 2 h / 0 - 25 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With ammonium cerium (IV) nitrate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.09.042

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 127431-10-1
2-(4-benzoyl-piperazin-1-ylmethyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 2 h / 70 °C

1.2: 2 h / 150 °C

2.1: dihydrogen peroxide; sodium bromide; acetic acid / 1 h / 40 °C

3.1: sodium methylate; copper(l) chloride; N,N-dimethyl-formamide / 4 h / 100 °C

4.1: hydrogen bromide / 1 h / 40 °C

5.1: ammonium cerium (IV) nitrate / water; tetrahydrofuran / 2 h / 0 - 20 °C

6.1: potassium carbonate / dichloromethane / 0.5 h / 40 °C / Green chemistry

With ammonium cerium (IV) nitrate; hydrogen bromide; dihydrogen peroxide; sodium methylate; potassium carbonate; hydrazine hydrate; acetic acid; N,N-dimethyl-formamide; sodium bromide; copper(l) chloride; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; ethylene glycol; 1.1: |Wolff-Kishner Reduction;
DOI:10.1016/j.bioorg.2016.08.008