4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal

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Chemical Name:4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal
CAS No.:797035-82-6
Molecular Formula:C₆₁H₈₉NO₁₀Si₂
Molecular Weight:1052.55
Hs Code.:

4-[6-(4-{2-[6-[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal

Synonyms:4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal

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Chemical Property of 4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal

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Technology Process of 4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal

There total 18 articles about 4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 797035-81-5
4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-en-1-ol

: 797035-82-6
4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal

Guidance literature:: With pyridine; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/chem.200500892

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 797035-82-6
4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal

Guidance literature:: Multi-step reaction with 12 steps

1.1: 79.3 percent / BF₃*Et₂O / CH₂Cl₂ / 0.5 h / 0 °C

2.1: 81 percent / dimethylsulfoxide / 12 h / 75 °C

3.1: DIBAL / toluene; CH₂Cl₂ / 1 h / -78 °C

4.1: 181 mg / NaBH₄ / methanol / 0.5 h / 0 °C

5.1: 92 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / 20 °C

6.1: HIO₄ / ethyl acetate / 6 h / 0 °C

7.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C

8.1: 49 mg / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

9.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

9.2: 78 percent / tetrahydrofuran / -78 - 20 °C

10.1: LiNEt₂ / tetrahydrofuran; hexane / 0.17 h / -78 °C

10.2: 61 percent / tetrahydrofuran; hexane / 0.67 h / -78 °C

11.1: 81 percent / PPTS / 12 h / 30 °C

12.1: 93 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; boron trifluoride diethyl etherate; lithium diethylamide; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; periodic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene; 8.1: Dess-Martin oxidation / 12.1: Dess-Martin oxidation;
DOI:10.1002/chem.200500892

Reference yield:

: 641613-75-4
(E)-(3R,5R,6R)-9-Acetoxy-3-methoxy-5,6-bis-(4-methoxy-benzyloxy)-8-methyl-non-7-enoic acid ethyl ester

: 797035-82-6
4-[6-(4-{2-[6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-2-ylmethyl)-4,6-dimethoxy-tetrahydro-pyran-2-yl]-2-methyl-4-triisopropylsilanyloxy-but-2-enal

Guidance literature:: Multi-step reaction with 7 steps

1.1: 97 percent / K₂CO₃ / ethanol / 2 h / 20 °C

2.1: 85 percent / CF₃COOH / CH₂Cl₂ / 1 h / 0 °C

3.1: 75 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / 20 °C

4.1: 78 percent / AgNO₃; pyridine / 24 h / 20 °C

5.1: LiNEt₂ / tetrahydrofuran; hexane / 0.17 h / -78 °C

5.2: 61 percent / tetrahydrofuran; hexane / 0.67 h / -78 °C

6.1: 81 percent / PPTS / 12 h / 30 °C

7.1: 93 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; dmap; lithium diethylamide; pyridinium p-toluenesulfonate; potassium carbonate; Dess-Martin periodane; silver nitrate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; 7.1: Dess-Martin oxidation;
DOI:10.1002/chem.200500892