8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS No.:864738-37-4
Molecular Formula:C₂₄H₂₅NO₄S
Molecular Weight:423.533
Hs Code.:

Synonyms:8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about 8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 864738-33-0
8-bromo-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 864738-37-4
8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; Heating;
DOI:10.1016/j.tet.2005.06.025

Reference yield:

: 864738-30-7
8-bromo-2-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-isoquinolin-4-one

: 864738-37-4
8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / InCl₃; Me₂SiHCl / CH₂Cl₂ / Heating

2: 49 percent / Pd(PPh₃)4; Na₂CO₃ / toluene; ethanol / Heating

With indium(III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylmonochlorosilane; sodium carbonate; In ethanol; dichloromethane; toluene; 2: Suzuki cross-coupling reaction;
DOI:10.1016/j.tet.2005.06.025

Reference yield:

: 864738-29-4
N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycyl chloride

: 864738-37-4
8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / AlCl₃ / CH₂Cl₂ / 4 h / -78 - -10 °C

2: 78 percent / InCl₃; Me₂SiHCl / CH₂Cl₂ / Heating

3: 49 percent / Pd(PPh₃)4; Na₂CO₃ / toluene; ethanol / Heating

With indium(III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; dimethylmonochlorosilane; sodium carbonate; In ethanol; dichloromethane; toluene; 1: intramolecular Friedel-Crafts cyclization / 3: Suzuki cross-coupling reaction;
DOI:10.1016/j.tet.2005.06.025