864738-33-0

Upstream product

• 864738-28-3 N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycine 
• 852358-46-4 methyl 2-[N-(2-bromobenzyl)amino]acetate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 
• 864738-27-2 methyl N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycinate 
• 864738-29-4 N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycyl chloride 
• 864738-30-7 8-bromo-2-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-isoquinolin-4-one 

Downstream Products

• 76304-20-6 8-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 864738-37-4 8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction

A versatile and efficient telescoped reaction sequence for the synthesis of tetrahydroisoquinolines (THIQs) is reported that uses TiCl4 to promote cyclization of a benzylaminoacetal derivative and Et3SiH for reduction of the intermediate 4-hydroxy-THIQ. This method is complimentary to the classical Pomeranz-Fritsch and related reactions since it tolerates electron-withdrawing substituents and allows access to 8-substituted THIQs.

Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions

New 8-(het)aryltetrahydroisoquinolines (10-14), 8- aryltetrahydroisoquinolin-4-ols (15,16), and 8-phenylisoquinolin-4-ol (17), flexible analogues of aporphine, were synthesized in good yields using palladium-catalyzed Suzuki cross-coupling reactions from