(+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

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Chemical Name:(+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate
CAS No.:1235994-46-3
Molecular Formula:C₂₆H₂₃F₂NO₃S
Molecular Weight:467.536
Hs Code.:

Synonyms:(+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

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Chemical Property of (+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

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Technology Process of (+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

There total 2 articles about (+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 89708-79-2
(R)-(+)-allyl p-tolyl sulphoxide

: 922-67-8
propynoic acid methyl ester

: 215859-23-7
2,2-difluoro-2-(2-naphthyl)acetonitrile

: 1235994-46-3
(+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

Guidance literature:: (R)-(+)-allyl p-tolyl sulphoxide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

2,2-difluoro-2-(2-naphthyl)acetonitrile; In tetrahydrofuran; toluene; at -78 ℃; for 1h; Inert atmosphere;

propynoic acid methyl ester; In tetrahydrofuran; toluene; at -78 ℃; Inert atmosphere;
DOI:10.1021/ol101318t

Reference yield:

: 1235994-37-2
(+)-(2Z,4E)-1,1-difluoro-1-(2-naphthyl)-5-[(R)-p-tolylsulfinyl]penta-2,4-dien-2-amine

: 922-67-8
propynoic acid methyl ester

: 1235994-46-3
(+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

Guidance literature:: In tetrahydrofuran; toluene; at -78 ℃; Inert atmosphere;
DOI:10.1021/ol101318t

Reference yield: 63.0%

: 1235994-46-3
(+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1235994-53-2
(+)-methyl N-benzyloxycarbonyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

Guidance literature:: (+)-methyl 6-[difluoro(2-naphthyl)methyl]-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; Inert atmosphere;

benzyl chloroformate; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol101318t