N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane

Base Information

Chemical Name:N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane
CAS No.:113812-13-8
Molecular Formula:C₃₈H₅₀N₄O₈S₄
Molecular Weight:819.101
Hs Code.:

N<sup>1</sup>,N<sup>4</sup>,N<sup>9</sup>,N<sup>12</sup>-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane

Synonyms:N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane

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Technology Process of N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane

There total 7 articles about N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 98-59-9
p-toluenesulfonyl chloride

: 113812-12-7
N¹,N¹,N¹²,N¹²-tetraethylspermine tetrahydrochloride

: 113812-13-8
N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane

Guidance literature:: With sodium hydroxide; In dichloromethane; 1.) 0 deg C, 1 h, 2.) room temperature, 2 d;
DOI:10.1021/jm00401a019

Reference yield:

: 107976-56-7
N,N'-bis(3-formamidopropyl)-N,N'-ditosyl-1,4-butanediamine

: 98-59-9
p-toluenesulfonyl chloride

: 113812-13-8
N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane

Guidance literature:: N,N'-bis(3-formamidopropyl)-N,N'-ditosyl-1,4-butanediamine; With hydrogenchloride; at 70 ℃; for 1h;

p-toluenesulfonyl chloride; With triethylamine; In pyridine; at 20 ℃; for 4h;
DOI:10.1016/S0968-0896(00)00156-5

Reference yield:

: 15544-47-5
N,N'-ditosyl-1,4-diaminobutane

: 113812-13-8
N¹,N⁴,N⁹,N¹²-tetra(p-toluenesulfonyl)-4,9-diaza-1,12-diaminododecane

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / Cs₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 83 percent / N₂H₄*H₂O / 23 h / 75 °C

3: 2M HCl / ethanol / 4 h / 80 °C

4: Et₃N, pyridine / 4 h / Ambient temperature

With pyridine; hydrogenchloride; caesium carbonate; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.62.198