15544-47-5

Upstream product

• 110-60-1 1,4-diaminobutane 
• 98-59-9 p-toluenesulfonyl chloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 13621-89-1 3,3'-[4,9-bis-(toluene-4-sulfonyl)-4,9-diaza-dodecane-1,12-diyl]-bis-oxazolidin-2-one 
• 109950-02-9 N-[2-Methoxy-1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-4-methyl-benzenesulfonamide 
• 126544-45-4 (Z)-1,6-Bis-(toluene-4-sulfonyl)-1,2,3,4,5,6,7,10-octahydro-[1,6]diazecine 
• 107976-61-4 N,N'-bis(3-phthalimidopropyl)-N,N'-ditosyl-1,4-butanediamine 
• 83492-51-7 C₁₈H₂₂N₂O₄S₂^(2-)*2Na⁽¹⁺⁾ 
• 102600-39-5 N,N'-dimethyl-N,N'-butanediyl-bis-toluene-4-sulfonamide 
• 84395-88-0 N⁴,N⁹-ditosyl-4,9-diaza-1,12-dodecanediol 
• 10297-36-6 N,N'-bis(2-hydroxyethyl)-N,N'-ditosyltetramethylenediamine 
• 114721-23-2 1,6-bis-(toluene-4-sulfonyl)-decahydro-[1,6]diazecine 
• 87338-06-5 1,6-bis(p-tolylsulfonyl)-1,6-diazacycloundecane 
• 107976-59-0 N¹,NN¹-phthaloyl-4,N⁸-ditosyl-4-azaoctane-1,8-diamine 
• 112300-64-8 1,5-bis-(toluene-4-sulfonyl)-octahydro-[1,5]diazonine 
• 277760-01-7 N¹,N⁵,N¹⁰,N¹⁴-tetra(p-toluenesulfonyl)-1,14-diamino-5,10-diazatetradecane 

Relevant academic research and scientific papers

Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control. (Chemical Equation Presented).

Quantitative structure-activity relationships studies for prediction of antimicrobial activity of synthesized disulfonamide derivatives

A new series of disulfonamides were synthesized and assayed as antimicrobial agents against Staphylococcus aureus, Bacillus cereus, and Escherichia coli. The quantitative structure-activity relationship analysis (QSAR) was applied to find out the correlat

A novel and efficient solvent-free and heterogeneous method for the synthesis of primary, secondary and bis-N-acylsulfonamides using metal hydrogen sulfate catalysts

Some metal hydrogen sulfates were used as acid catalysts in the N-acylation of different sulfonamides using carboxylic acid chlorides and anhydrides as acylating agents under both heterogeneous and solvent-free conditions. Al(HSO4)3

Condensation of Alkanediamines with Formaldehyde; Intramolecular Disproportionation of N-Hydroxymethyl Groups into N-Methyl and N-Formyl Groups

The condensation of α,ω-alkanediamines NH2(CN2)nNH2 with aqueous formaldehyde has been studied by NMR spectroscopy of isolated products and of product mixtures.The condensation was reversible and gave products of widely different types depending on alkane chain length: bicyclic oxadiaza compounds (n = 2, 3, 4), a tricyclic tetraaza compound (n = 2), a quinquecyclic octaaza compound (n = 3), two-dimensional polymers (n = 4, 5).A slow irreversible rearrangement gave in two cases (n = 3, 4), unicyclic 1-formyl-3-methyl-1,3-diaza compounds.The condensation of N,N'-dimethyl-α,ω-alkandediamines CH3NH(CH2)nNHCH3 with aqueous formaldehyde was also studied.The reversible formation of simple unicyclic diaza compounds was observed in all cases (n = 2, 3, 4), but in one case (n = 2) there was again a slow irreversible rearrangement to the N-formyl-N,N'N'-trimethyl derivative.The rearrangement reaction involves a hydride shift and is strictly intramolecular.The conditions for its occurrence can be understood on a conformational basis.

Macrocyclic Polyamines -N3 and -N4: Synthesis and Study of their ATP Complexation by 31P Nuclear Magnetic Resonance Spectroscopy

The macrocyclic polyamines -N3, compound 1, and -N4, compound 2, possessing a hydroxymethyl side-chain have been synthesized.The macrocyclisation was achieved by condensation of lysine ditosate 3b with appropriate components 5 and 6 in the presence of CsCO3 to obtain 7 and 8 in 33 and 37percent yield, respectively.The complexation of polyamines 1 and 2 with ATP was studied by 31P NMR spectroscopy, which indicated a specific recognition of γ-phosphorus of ATP (NMe4 salt) by the polyamines.The binding constant estimates indicated that ATP binds compound 2 ca. 35-times stronger than it does compound 1.The binding curves indicated a definite 1:1 stoicheiometry for 2:ATP complex, and not so well defined stoicheiometry for 1:ATP binding.The mononucleotides, AMP and cAMP, and dinucleotide TpT did not show significant complexation with either compound 1 or 2.The binding of ATP by macrocyclic polyamines 1 and 2 and the presence of a hydroxymethyl side-chain to link with a nucleophile may aid rational design of chemical nucleases.

Preferential Introduction of a Pyridylmethyl Group into Sulfonamides as an Approach to an Intramolecular Transimination

N,N'-Bis(p-tolylsulfonyl)-α,ω-alkanediamine disodium salts (n=3, 4, 5, 6, 7, 8, 9, 10) were subjected to monopyridylmethylation by the reaction with 5'-deoxy-5'-chloro- or 5'-deoxy-2'-chloro-3,4'-O-isopropylidenepyridoxine hydrochloride, accompanied by th

Dynamic Protection of Amines using 18-Crown-6

The regioselectivity of diamine monoacylation has been controlled by selective complexation with 18-crown-6 and a proton source.