N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine

Base Information

• Chemical Name: N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine
• CAS No.: 849065-15-2
• Molecular Formula: C₂₉H₂₇NO₃
• Molecular Weight: 437.538

Synonyms:N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine

Chemical Property of N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine

There total 2 articles about N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(+/-)-3-benzyl-3,4-dihydro-2H-1,4-benzoxazine (55000-22-1) + (S)-naproxenoyl chloride (51091-84-0) → N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine (849065-15-2)

Guidance literature:

In benzene; at 20 ℃; for 5h;

DOI:10.1021/jo048212s

Reference yield:

3-benzyl-4-acetyl-3,4-dihydro-2H-1,4-benzoxazine → N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine (849065-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / KOH / H₂O; methanol / 12 h / 50 - 60 °C

2: 88 percent / benzene / 5 h / 20 °C

With potassium hydroxide; In methanol; water; benzene;

DOI:10.1021/jo048212s

Reference yield: 75.0%

N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine (849065-15-2) → (S)-3-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

Guidance literature:

With hydrogenchloride; acetic acid; for 5h; Heating;

DOI:10.1021/jo048212s

upstream raw materials:

(+/-)-3-benzyl-3,4-dihydro-2H-1,4-benzoxazine

(S)-naproxenoyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 849065-15-2 N-[(2S)-2-(6-methoxy-2-naphthyl)propionyl]-(3S)-2,3-dihydro-3-benzyl-4H-1,4-benzoxazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send