N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine

Base Information

Chemical Name:N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine
CAS No.:1434557-50-2
Molecular Formula:C₅₈H₈₃NO₁₅
Molecular Weight:1034.29
Hs Code.:

Synonyms:N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine

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Technology Process of N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine

There total 1 articles about N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2018-66-8
Z-Leu-OH

: 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyloleanate acid

: 1434557-50-2
N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 12h;
DOI:10.1021/jm400393u

Reference yield: 83.0%

: 1434557-50-2
N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine

: 1434557-86-4
N-Cbz-1-(S)-(2-methyl)propyl-2-(β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine

Guidance literature:: With sodium methylate; In methanol; dichloromethane; at 0 - 25 ℃; pH=9;
DOI:10.1021/jm400393u

Reference yield:

: 1434557-50-2
N-Cbz-1-(S)-(2-methyl)propyl-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl olean-12-en-28-oate-3-yl)oxy-2-oxoethylamine

: 1434558-52-7
C₅₁H₇₈N₆O₁₆

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / dichloromethane; methanol / 0 - 25 °C / pH 9

2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 10 h / 25 °C

3: sodium carbonate / tetrahydrofuran / 25 °C

With palladium 10% on activated carbon; hydrogen; sodium methylate; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm400393u