Technology Process of 1-benzyloxy-3,7-dimethyl-20-N-phthalimido-6,8-eicosadiene
There total 10 articles about 1-benzyloxy-3,7-dimethyl-20-N-phthalimido-6,8-eicosadiene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
8-benzyloxy-2,6-dimethyl-2-octenyltriphenylphosphonium bromide;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at 20 ℃;
for 0.75h;
12-N-phthalimidododecanal;
In
tetrahydrofuran;
for 16h;
Further stages.;
DOI:10.1039/b206451k
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: NaH / tetrahydrofuran; hexane / 2 h / Heating
1.2: 58 percent / tetrabutylammonium iodide / tetrahydrofuran; hexane / 18 h / Heating
2.1: 12 percent / SeO2; t-BuOOH / CH2Cl2; H2O / 16 h
3.1: 33 percent / NaBH4 / ethanol; CH2Cl2; H2O / 16 h
4.1: Et3N; MeSO2Cl / CH2Cl2 / 1 h / -50 °C
4.2: 71 percent / LiBr / tetrahydrofuran; CH2Cl2 / 2 h / -20 °C
5.1: 97 percent / toluene / 144 h / in the dark
6.1: LDA / tetrahydrofuran / 0.75 h / 20 °C
6.2: 52 percent / tetrahydrofuran / 16 h
With
tert.-butylhydroperoxide; sodium tetrahydroborate; selenium(IV) oxide; sodium hydride; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene;
DOI:10.1039/b206451k
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 12 percent / SeO2; t-BuOOH / CH2Cl2; H2O / 16 h
2.1: 33 percent / NaBH4 / ethanol; CH2Cl2; H2O / 16 h
3.1: Et3N; MeSO2Cl / CH2Cl2 / 1 h / -50 °C
3.2: 71 percent / LiBr / tetrahydrofuran; CH2Cl2 / 2 h / -20 °C
4.1: 97 percent / toluene / 144 h / in the dark
5.1: LDA / tetrahydrofuran / 0.75 h / 20 °C
5.2: 52 percent / tetrahydrofuran / 16 h
With
tert.-butylhydroperoxide; sodium tetrahydroborate; selenium(IV) oxide; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1039/b206451k
