methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate
CAS No.:1609201-03-7
Molecular Formula:C₂₃H₂₄FNO₆S
Molecular Weight:461.511
Hs Code.:

Synonyms:methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

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Chemical Property of methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

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Technology Process of methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

There total 12 articles about methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112399-50-5
2-bromo-5-fluorobenzyl bromide

: 1609201-03-7
methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / toluene / 20 h / 60 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark; Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 - 20 °C

3.3: 0.5 h / 20 °C

4.1: pyridine / dichloromethane / 17 h / 20 °C

5.1: hydrogenchloride / water; tetrahydrofuran / 1.5 h / 60 °C

With pyridine; hydrogenchloride; n-butyllithium; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; water; toluene;

Reference yield:

: 1412976-22-7
methyl (1aR,7bS)-5-amino-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609201-03-7
methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 17 h / 20 °C

2: hydrogenchloride / water; tetrahydrofuran / 1.5 h / 60 °C

With pyridine; hydrogenchloride; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1412976-20-5
methyl 5-(2,2-dimethylpropionylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609201-03-7
methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / methanol / 60 h / Inert atmosphere; Reflux

2: Lux C-3 column / methanol; diethylamine; carbon dioxide / Supercritical conditions; liquid CO₂

3: pyridine / dichloromethane / 17 h / 20 °C

4: hydrogenchloride / water; tetrahydrofuran / 1.5 h / 60 °C

With pyridine; hydrogenchloride; sulfuric acid; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide; water; diethylamine;