methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate
CAS No.:1609201-02-6
Molecular Formula:C₂₇H₃₅FN₂O₅S
Molecular Weight:518.65
Hs Code.:

methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Synonyms:methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Chemical Property of methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Technology Process of methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

There total 14 articles about methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609201-03-7
methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

: 109-89-7
diethylamine

: 1609201-02-6
methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 168h;

Reference yield:

: 112399-50-5
2-bromo-5-fluorobenzyl bromide

: 1609201-02-6
methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / toluene / 20 h / 60 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark; Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 - 20 °C

3.3: 0.5 h / 20 °C

4.1: pyridine / dichloromethane / 17 h / 20 °C

5.1: hydrogenchloride / water; tetrahydrofuran / 1.5 h / 60 °C

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 168 h / 20 °C

With pyridine; hydrogenchloride; n-butyllithium; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; water; toluene;

Reference yield:

: 1412976-22-7
methyl (1aR,7bS)-5-amino-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609201-02-6
methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 17 h / 20 °C

2: hydrogenchloride / water; tetrahydrofuran / 1.5 h / 60 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 168 h / 20 °C

With pyridine; hydrogenchloride; sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; water;