Technology Process of C18H27NO4
There total 4 articles about C18H27NO4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
at 0 ℃;
for 3h;
pH=8;
aq. buffer;
DOI:10.3987/COM-10-S(E)76
- Guidance literature:
-
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / diethyl ether / 0.5 h / -78 °C
2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 0 - 20 °C
3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 3 h / 0 °C / pH 8 / aq. buffer
With
boron trifluoride diethyl etherate; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
2: Williamson etherification;
DOI:10.3987/COM-10-S(E)76
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 4.5 h / 0 - 20 °C
2: boron trifluoride diethyl etherate / diethyl ether / 0.5 h / -78 °C
3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 0 - 20 °C
4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 3 h / 0 °C / pH 8 / aq. buffer
With
boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
3: Williamson etherification;
DOI:10.3987/COM-10-S(E)76
