1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane

Base Information

Chemical Name:1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane
CAS No.:117152-74-6
Molecular Formula:C₃₂H₄₈N₄O₈S₂
Molecular Weight:680.887
Hs Code.:

Synonyms:1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane

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Chemical Property of 1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane

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Technology Process of 1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane

There total 3 articles about 1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 105-36-2
ethyl bromoacetate

: 117152-72-4
1,8-N,N'-bis(p-toluenesulphonyl)-1,4,8,11-tetraazacyclotetradecane

: 117152-74-6
1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: With sodium carbonate; In acetonitrile; for 18h; Heating;
DOI:10.1016/0040-4020(89)80049-3

Reference yield:

: 295-37-4
1,4,8,11-Tetraazacyclotetradecane

: 117152-74-6
1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / triethylamine / CH₂Cl₂ / 18 h / 5 °C

2: 91 percent / Na₂CO₃ / acetonitrile / 18 h / Heating

With sodium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/0040-4020(89)80049-3

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 117152-74-6
1,8-N,N'-bis(toluenesulphonyl)-4,11-bis(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / triethylamine / CH₂Cl₂ / 18 h / 5 °C

2: 91 percent / Na₂CO₃ / acetonitrile / 18 h / Heating

With sodium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/0040-4020(89)80049-3