3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester

Base Information

• Chemical Name: 3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester
• CAS No.: 126541-90-0
• Molecular Formula: C₉H₆F₃NO₅
• Molecular Weight: 265.146
• Mol file: 126541-90-0.mol

Synonyms:3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester

Chemical Property of 3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester

There total 5 articles about 3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

3-Hydroxy-4-(trifluormethyl)benzoesaeure-methylester (126541-88-6) → 3-Hydroxy-2-nitro-4-(trifluormethyl)benzoesaeure-methylester (126541-89-7) + 3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester (126541-90-0)

Guidance literature:

With nitric acid; In acetic acid; at 50 ℃;

Reference yield:

4-trifluoromethylbenzoic acid (455-24-3) → 3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester (126541-90-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 25 percent / HNO₃ (d=1.5) / 1 h / Heating

2: 88 percent / H₂ / Pd/A-Kohle / methanol

3: 70 percent / NaNO₂, aq. H₂SO₄ / acetic acid / -5 deg C, 15 min, then room temp., 2h, then reflux, 3 min

4: 55 mg / methanol; diethyl ether / 0.25 h

5: 49 percent / HNO₃ (d=1.42) / acetic acid / 50 °C

With sulfuric acid; hydrogen; nitric acid; sodium nitrite; A-Kohle; palladium; In methanol; diethyl ether; acetic acid;

Reference yield:

3-nitro-4-(trifluoromethyl)benzoic acid (116965-16-3) → 3-Hydroxy-6-nitro-4-(trifluormethyl)benzoesaeure-methylester (126541-90-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / H₂ / Pd/A-Kohle / methanol

2: 70 percent / NaNO₂, aq. H₂SO₄ / acetic acid / -5 deg C, 15 min, then room temp., 2h, then reflux, 3 min

3: 55 mg / methanol; diethyl ether / 0.25 h

4: 49 percent / HNO₃ (d=1.42) / acetic acid / 50 °C

With sulfuric acid; hydrogen; nitric acid; sodium nitrite; A-Kohle; palladium; In methanol; diethyl ether; acetic acid;

upstream raw materials:

3-Hydroxy-4-(trifluormethyl)benzoesaeure-methylester

4-trifluoromethylbenzoic acid

3-hydroxy-4-trifluoromethylbenzoic acid

3-amino-4-(trifluoromethyl)benzoic acid

Downstream raw materials:

5-Hydroxy-2-nitro-4-trifluoromethyl-benzoic acid