(3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Base Information

Chemical Name:(3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester
CAS No.:216171-44-7
Molecular Formula:C₃₀H₃₁NO₆
Molecular Weight:501.579
Hs Code.:

Synonyms:(3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Suppliers and Price of (3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of (3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

There total 1 articles about (3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 105228-46-4,335159-14-3
(5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 216171-44-7
(3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; 1.) -78 deg C, 40 min, 2.) -78 deg C, 2 h;
DOI:10.1055/s-1998-1884

Reference yield: 63.0%

: 216171-44-7
(3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

: 74-88-4
methyl iodide

: 216171-45-8
(3S,5R,6S)-3-tert-Butoxycarbonylmethyl-3-methyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Guidance literature:: With 15-crown-5; sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1055/s-1998-1884

Reference yield:

: 216171-44-7
(3R,5R,6S)-3-tert-Butoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

: 216171-42-5
(3S,5R,6S)-3-Carbamoylmethyl-3-methyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaN(TMS)2, 15-crown-5 / tetrahydrofuran / 1 h / -78 °C

2: TFA / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) r.t., 1 h

3: NH₄HCO₃, EEDQ / CHCl₃ / 12 h / Ambient temperature

With 15-crown-5; sodium hexamethyldisilazane; ammonium bicarbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1055/s-1998-1884