methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate

Base Information

• Chemical Name: methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate
• CAS No.: 1235467-68-1
• Molecular Formula: C₁₈H₁₈BrN₃O₄
• Molecular Weight: 420.263
• Mol file: 1235467-68-1.mol

Synonyms:methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate

Chemical Property of methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate

There total 1 articles about methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

4-(morpholine-4-carbonyl)phenylboronic acid (389621-84-5) + 3-amino-2,6-dibromo-isonicotinic acid methyl ester (28033-01-4) → methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate (1235467-68-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene; at 110 ℃; for 64h; Inert atmosphere;

Reference yield: 72.0%

methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate (1235467-68-1) → methyl 3-azido-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate (1235467-69-2)

Guidance literature:

methyl 3-amino-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate; With sodium nitrite; In trifluoroacetic acid; for 0.5h; Cooling with ice;

With sodium azide; In diethyl ether; trifluoroacetic acid; for 0.5h; Cooling with ice;

upstream raw materials:

4-(morpholine-4-carbonyl)phenylboronic acid

3-amino-2,6-dibromo-isonicotinic acid methyl ester

Downstream raw materials:

methyl 3-azido-6-bromo-2-(4-(morpholine-4-carbonyl)phenyl)-isonicotinate