1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine

Base Information

Chemical Name:1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine
CAS No.:1400691-93-1
Molecular Formula:C₂₀H₂₂FN₅O
Molecular Weight:367.426
Hs Code.:

Synonyms:1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine

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Technology Process of 1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine

There total 4 articles about 1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1400692-25-2
C₂₀H₂₂FN₃O₂S

: 60-34-4
methylhydrazine

: 1400691-93-1
1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine

Guidance literature:: In tert-butyl alcohol; for 2h; Reflux;

Reference yield:

: 1400692-24-1
C₁₉H₂₀FN₃O₂S

: 1400691-93-1
1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: tert-butyl alcohol / 2 h / Reflux

With potassium carbonate; In acetone; tert-butyl alcohol;

Reference yield:

: 133244-56-1
N-(4-fluorobenzoyl)thiourea

: 1400691-93-1
1-[5-(4-fluorophenyl)-1-methyl-1H-1,2,4-triazol-3-yl]-4-(4-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetone / 1 h / 20 °C

2.1: potassium carbonate / acetone / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: tert-butyl alcohol / 2 h / Reflux

With potassium carbonate; In acetone; tert-butyl alcohol;