3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate

Base Information

Chemical Name:3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate
CAS No.:1378029-26-5
Molecular Formula:C₁₇H₂₆N₂O₉S
Molecular Weight:434.467
Hs Code.:

Synonyms:3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate

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Chemical Property of 3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate

Chemical Property:

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Technology Process of 3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate

There total 1 articles about 3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

: 1378029-25-4
tert-butyl (1-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl)carbamate

: 124-63-0
methanesulfonyl chloride

: 1378029-26-5
3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1039/c2cc31281f

Reference yield: 57.9%

: 1378029-26-5
3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate

: 81526-29-6
N,N-bis(2-(ethylthio)ethyl)amine

: 1378029-27-6
tert-butyl (3-(bis(2-(ethylthio)ethyl)amino)-1-(4,5-dimethoxy-2-nitrophenyl)propyl)carbamate

Guidance literature:: N,N-bis(2-(ethylthio)ethyl)amine; With 18-crown-6 ether; potassium carbonate; In acetonitrile; for 0.5h; Reflux;

3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate; In acetonitrile; for 1h; Reflux;
DOI:10.1039/c2cc31281f

Reference yield:

: 1378029-26-5
3-((tert-butoxycarbonyl)amino)-3-(4,5-dimethoxy-2-nitrophenyl)propyl methanesulfonate

: 1378029-32-3
2-(bis(2-(ethylthio)ethyl)amino)-N-(3-(bis(2-(ethylthio)ethyl)amino)-1-(4,5-dimethoxy-2-nitrophenyl)propyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 18-crown-6 ether; potassium carbonate / acetonitrile / 0.5 h / Reflux

1.2: 1 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 3 h / 23 °C

3.1: 18-crown-6 ether; potassium carbonate / acetonitrile / 2 h / 23 °C

With 18-crown-6 ether; potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1039/c2cc31281f