5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

Base Information

Chemical Name:5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil
CAS No.:155831-66-6
Molecular Formula:C₂₇H₃₆N₂O₄SSi
Molecular Weight:512.745
Hs Code.:

Synonyms:5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

Suppliers and Price of 5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

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Technology Process of 5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

There total 7 articles about 5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4212-49-1
5-ethyluracil

: 155831-66-6
5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium sulfate / 2 h / Heating

2: K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

3: 90 percent / K₂CO₃ / methanol / Ambient temperature

4: 73 percent / imidazole / dimethylformamide / Ambient temperature

5: 1.) LDA / 1.) heptane, THF, ethylbenzene, -78 deg C, 1 h, 2.) heptane, THF, ethylbenzene, from -78 deg C to -50 deg C, overnight

With 1H-imidazole; ammonium sulfate; potassium carbonate; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570310130

Reference yield:

: 10335-95-2
2-hydroxy-2-phenylethyl benzoate

: 155831-66-6
5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

Guidance literature:: Multi-step reaction with 5 steps

1: HCl(g) / CH₂Cl₂ / 0 °C

2: K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

3: 90 percent / K₂CO₃ / methanol / Ambient temperature

4: 73 percent / imidazole / dimethylformamide / Ambient temperature

5: 1.) LDA / 1.) heptane, THF, ethylbenzene, -78 deg C, 1 h, 2.) heptane, THF, ethylbenzene, from -78 deg C to -50 deg C, overnight

With 1H-imidazole; hydrogenchloride; potassium carbonate; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570310130

Reference yield:

: 156192-65-3
Benzoic acid 2-chloromethoxy-2-phenyl-ethyl ester

: 155831-66-6
5-ethyl-1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

2: 90 percent / K₂CO₃ / methanol / Ambient temperature

3: 73 percent / imidazole / dimethylformamide / Ambient temperature

4: 1.) LDA / 1.) heptane, THF, ethylbenzene, -78 deg C, 1 h, 2.) heptane, THF, ethylbenzene, from -78 deg C to -50 deg C, overnight

With 1H-imidazole; potassium carbonate; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570310130