Technology Process of 2-(4-iodonaphthalen-2-ylamino)-5-nitrobenzoic acid
There total 11 articles about 2-(4-iodonaphthalen-2-ylamino)-5-nitrobenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
Reflux;
DOI:10.1124/mol.113.087502
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
for 1h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / ethanol / 4 h / 20 °C
2.1: sodium nitrite; sulfuric acid; acetic acid / 2 h / 10 - 20 °C
2.2: 1 h / 10 - 55 °C
3.1: tin(II) chloride dihdyrate / ethanol / 3 h / Reflux
4.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 20 - 130 °C
5.1: sodium iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / 120 h / 110 °C
6.1: lithium hydroxide; water / methanol; tetrahydrofuran / Reflux
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; copper(l) iodide; tin(II) chloride dihdyrate; sulfuric acid; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; water; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium iodide; lithium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; ethanol; toluene;
4.1: |Buchwald-Hartwig Coupling;
DOI:10.1124/mol.113.087502
