4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester

Base Information

Chemical Name:4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester
CAS No.:871834-48-9
Molecular Formula:C₂₄H₂₃BrF₆N₂O₄
Molecular Weight:597.352
Hs Code.:

Synonyms:4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester

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Chemical Property of 4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester

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Technology Process of 4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester

There total 9 articles about 4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 871834-47-8
(3,5-bis-trifluoromethylphenyl)-(7-bromo-3-ethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetic acid methyl ester

: 541-41-3
chloroformic acid ethyl ester

: 871834-48-9
4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester

Guidance literature:: (3,5-bis-trifluoromethylphenyl)-(7-bromo-3-ethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetic acid methyl ester; chloroformic acid ethyl ester; With pyridine; In dichloromethane; at 20 ℃; for 0.0833333h;

With hydrogenchloride; In dichloromethane; water;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 940001-55-8
C₁₁H₁₆N₂O₅S

: 871834-48-9
4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

2: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

3: 60 percent / TBAI; K₂CO₃ / dimethylformamide

4: NBS / dimethylformamide

5: pyridine / CH₂Cl₂

With pyridine; N-Bromosuccinimide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.112

Reference yield:

: 940001-54-7
C₁₀H₁₄N₂O₃

: 871834-48-9
4-[(3,5-bis-trifluoromethylphenyl)-methoxycarbonyl-methyl]-6-bromo-2-ethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂

2: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

3: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

4: 60 percent / TBAI; K₂CO₃ / dimethylformamide

5: NBS / dimethylformamide

6: pyridine / CH₂Cl₂

With pyridine; N-Bromosuccinimide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.112