(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine

Base Information

Chemical Name:(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine
CAS No.:1402004-27-6
Molecular Formula:C₁₃H₁₇ClF₃NO
Molecular Weight:295.732
Hs Code.:

Synonyms:(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine

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Chemical Property of (2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine

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Technology Process of (2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine

There total 5 articles about (2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1402004-26-5
tert-butyl {(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}carbamate

: 1402004-27-6
(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine

Guidance literature:: tert-butyl {(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}carbamate; With trifluoroacetic acid; In dichloromethane; for 0.5h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 886371-34-2
1-(5-chloro-2-methoxyphenyl)-2,2,2-trifluoroethanone

: 1402004-27-6
(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran / -78 - 0 °C

1.2: 0.08 h

2.1: thionyl chloride; pyridine / 16 h / 40 °C

3.1: dichloromethane; hexane / -78 - 20 °C

3.2: -78 °C

4.1: boron tribromide / dichloromethane / -78 - 40 °C

4.2: -78 °C

4.3: pH 5

5.1: caesium carbonate / N,N-dimethyl-formamide / 18.5 h / 60 °C

6.1: trifluoroacetic acid / dichloromethane / 0.5 h

With pyridine; thionyl chloride; boron tribromide; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1402004-23-2
4-chloro-2-(2-chloro-1,1,1-trifluoropropan-2-yl)-1-methoxybenzene

: 1402004-27-6
(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane; hexane / -78 - 20 °C

1.2: -78 °C

2.1: boron tribromide / dichloromethane / -78 - 40 °C

2.2: -78 °C

2.3: pH 5

3.1: caesium carbonate / N,N-dimethyl-formamide / 18.5 h / 60 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h

With boron tribromide; caesium carbonate; trifluoroacetic acid; In hexane; dichloromethane; N,N-dimethyl-formamide;