N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Base Information

Chemical Name:N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide
CAS No.:1402004-28-7
Molecular Formula:C₂₅H₂₈ClF₃N₄O₄
Molecular Weight:540.97
Hs Code.:

N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Synonyms:N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

There total 8 articles about N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1402004-16-3
7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydropyrido[2,1-c]-[1,4]oxazine-1,6-dione

: 1402004-27-6
(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine

: 1402004-28-7
N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Guidance literature:: (2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-amine; With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; In tetrahydrofuran; at 40 ℃; for 0.75h;

7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydropyrido[2,1-c]-[1,4]oxazine-1,6-dione; In tetrahydrofuran; at 40 - 70 ℃; for 6.08333h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃;

Reference yield:

: 1123194-98-8
6-bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine

: 1402004-28-7
N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate; water; methanol / 1 h / 70 °C / 375.04 - 2250.23 Torr

2.1: hydrogenchloride / 1,4-dioxane; water / 18 h / Reflux

3.1: caesium carbonate / dichloromethane / 6 h / 90 °C

4.1: bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct / tetrahydrofuran / 0.75 h / 40 °C

4.2: 6.08 h / 40 - 70 °C

4.3: 0 °C

With hydrogenchloride; bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; caesium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 886371-34-2
1-(5-chloro-2-methoxyphenyl)-2,2,2-trifluoroethanone

: 1402004-28-7
N-{(2S)-1-[4-chloro-2-(1,1,1-trifluoro-2-methylpropan-2-yl)phenoxy]propan-2-yl}-1-(2-hydroxyethyl)-5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethyl ether; tetrahydrofuran / -78 - 0 °C

1.2: 0.08 h

2.1: thionyl chloride; pyridine / 16 h / 40 °C

3.1: dichloromethane; hexane / -78 - 20 °C

3.2: -78 °C

4.1: boron tribromide / dichloromethane / -78 - 40 °C

4.2: -78 °C

4.3: pH 5

5.1: caesium carbonate / N,N-dimethyl-formamide / 18.5 h / 60 °C

6.1: trifluoroacetic acid / dichloromethane / 0.5 h

7.1: bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct / tetrahydrofuran / 0.75 h / 40 °C

7.2: 6.08 h / 40 - 70 °C

7.3: 0 °C

With pyridine; thionyl chloride; bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; boron tribromide; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;