6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene

Base Information

Chemical Name:6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene
CAS No.:1296257-58-3
Molecular Formula:C₂₈H₂₄F₂O₄
Molecular Weight:462.493
Hs Code.:

Synonyms:6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene

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Chemical Property of 6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene

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Technology Process of 6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene

There total 7 articles about 6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1296257-66-3
5-allyloxy-5'-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)benzophenone

: 1296257-58-3
6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene

Guidance literature:: In toluene; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/jo200303c

Reference yield:

: 1015414-82-0
(2,5-difluoro-4-nitrophenyl)(2-fluoro-5-methoxyphenyl)methanone

: 1296257-58-3
6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene

Guidance literature:: Multi-step reaction with 5 steps

1: water; hydrogen bromide; acetic acid / 36 h / Reflux

2: potassium carbonate / 108 h / 20 - 50 °C / Inert atmosphere

3: sodium hydride; Benzaldoxime / dimethyl sulfoxide; mineral oil / 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

5: toluene / 24 h / Inert atmosphere; Reflux

With water; hydrogen bromide; sodium hydride; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; Benzaldoxime; copper dichloride; In dichloromethane; dimethyl sulfoxide; toluene; mineral oil; 5: Claisen cyclization;
DOI:10.1021/jo200303c

Reference yield:

: 1296257-57-2
5-allyloxy-5'-benzyloxy-2,2'-difluoro-4-nitrobenzophenone

: 1296257-58-3
6-(5-benzyloxy-2-fluorobenzoyl)-2,2-dimethyl-5-fluoro-8-allyloxychromene

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride; Benzaldoxime / dimethyl sulfoxide; mineral oil / 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3: toluene / 24 h / Inert atmosphere; Reflux

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; Benzaldoxime; copper dichloride; In dichloromethane; dimethyl sulfoxide; toluene; mineral oil; 3: Claisen cyclization;
DOI:10.1021/jo200303c