O⁶-2-(4-nitrophenyl)ethylguanine

Base Information

• Chemical Name: O⁶-2-(4-nitrophenyl)ethylguanine
• CAS No.: 213902-34-2
• Molecular Formula: C₁₃H₁₂N₆O₃
• Molecular Weight: 300.277
• Mol file: 213902-34-2.mol

Synonyms:O⁶-2-(4-nitrophenyl)ethylguanine

Chemical Property of O⁶-2-(4-nitrophenyl)ethylguanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O⁶-2-(4-nitrophenyl)ethylguanine

There total 5 articles about O⁶-2-(4-nitrophenyl)ethylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N2-acetyl-O6-(2-(p-nitrophenyl)ethyl)guanine (218152-30-8) → O6-2-(4-nitrophenyl)ethylguanine (213902-34-2)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 48h;

DOI:10.1080/15257770500267113

Reference yield: 69.0%

N2,N9-diacetyl-O6-2-(4-nitrophenyl)ethylguanine (917376-69-3) → O6-2-(4-nitrophenyl)ethylguanine (213902-34-2)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 48h;

DOI:10.1080/15257770500267113

Reference yield: 27.0%

2-(4-nitrophenyl)ethanol (100-27-6) + 2-Amino-6-chloropurin (10310-21-1) → O6-2-(4-nitrophenyl)ethylguanine (213902-34-2)

Guidance literature:

With sodium hydride; In 1,4-dioxane; for 4h; Reflux;

DOI:10.2174/1573406412666160710210907

upstream raw materials:

N²-acetyl-O⁶-(2-(p-nitrophenyl)ethyl)guanine

N²,N⁹-diacetyl-O⁶-2-(4-nitrophenyl)ethylguanine

2-(4-nitrophenyl)ethanol

2,9-diacetylguanine

Downstream raw materials:

{9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

(6-[2-(4-Nitro-phenyl)-ethoxy]-9-{(2R,3R,3aS,9aR)-5,5,7,7-tetraisopropyl-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-9H-purin-2-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

{9-{(2R,3R,4S,5R)-4-Hydroxy-5-hydroxymethyl-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

((2R,3R,3aS,9aR)-2-{2-Amino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester