(S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

Base Information

Chemical Name:(S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide
CAS No.:1415255-72-9
Molecular Formula:C₃₆H₃₇N₃O₃
Molecular Weight:559.708
Hs Code.:

Synonyms:(S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

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Chemical Property of (S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

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Technology Process of (S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

There total 12 articles about (S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415257-75-8
(S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

: 1415255-72-9
(S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/acsmedchemlett.5b00218

Reference yield:

: 1415253-92-7
(S)-4'-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

: 1415255-72-9
(S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.08 h

1.2: 0.5 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;
DOI:10.1021/acsmedchemlett.5b00218

Reference yield:

: 34246-57-6
3-isopropylbenzaldehyde

: 1415255-72-9
(S)-1-((2'-(hydroxycarbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropyl phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridinium p-toluenesulfonate; magnesium sulfate / dichloromethane / 40 °C

2.1: dichloromethane; diethyl ether / 22 h / -50 - 20 °C

3.1: hydrogenchloride / water; methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.08 h

4.2: 0.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.08 h

6.2: 0.5 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; pyridinium p-toluenesulfonate; magnesium sulfate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/acsmedchemlett.5b00218