(S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

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Chemical Name:(S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide
CAS No.:1415257-75-8
Molecular Formula:C₄₂H₅₁N₃O₃Si
Molecular Weight:673.971
Hs Code.:

Synonyms:(S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

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Chemical Property of (S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

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Technology Process of (S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

There total 11 articles about (S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415253-92-7
(S)-4'-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

: 41879-39-4
O-(tert-butyldimethylsilanyl)hydroxylamine

: 1415257-75-8
(S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

Guidance literature:: (S)-4'-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; for 0.0833333h;

O-(tert-butyldimethylsilanyl)hydroxylamine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/acsmedchemlett.5b00218

Reference yield:

: 34246-57-6
3-isopropylbenzaldehyde

: 1415257-75-8
(S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridinium p-toluenesulfonate; magnesium sulfate / dichloromethane / 40 °C

2.1: dichloromethane; diethyl ether / 22 h / -50 - 20 °C

3.1: hydrogenchloride / water; methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.08 h

4.2: 0.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.08 h

6.2: 0.5 h / 20 °C

With hydrogenchloride; pyridinium p-toluenesulfonate; magnesium sulfate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/acsmedchemlett.5b00218

Reference yield:

: (R,E)-N-(3-isopropylbenzylidene)-2-methylpropane-2-sulfinamide

: 1415257-75-8
(S)-1-((2'-(((tert-butyldimethylsilyl)oxy)carbamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane; diethyl ether / 22 h / -50 - 20 °C

2.1: hydrogenchloride / water; methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.08 h

3.2: 0.5 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.08 h

5.2: 0.5 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/acsmedchemlett.5b00218