[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester

Base Information

Chemical Name:[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester
CAS No.:288854-06-8
Molecular Formula:C₂₇H₂₆BrNO₃
Molecular Weight:492.412
Hs Code.:

[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1<i>H</i>-indol-3-yl]-acetic acid phenethyl ester

Synonyms:[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester

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Chemical Property of [1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester

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Technology Process of [1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester

There total 3 articles about [1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 589-15-1
1-bromomethyl-4-bromobenzene

: 288854-00-2
5-methoxy-2-methylindole 3-phenethylacetate

: 288854-06-8
[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester

Guidance literature:: 5-methoxy-2-methylindole 3-phenethylacetate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

1-bromomethyl-4-bromobenzene; In N,N-dimethyl-formamide; Further stages.;
DOI:10.1021/jm000004e

Reference yield:

: 60-12-8
2-phenylethanol

: 288854-06-8
[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: BOP-Cl; Et₃N / CH₂Cl₂ / 0.17 h / 20 °C

1.2: 67 percent / CH₂Cl₂ / 20 °C

2.1: NaH / dimethylformamide / 0.33 h / 0 °C

2.2: 73 percent / dimethylformamide

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 1.2: Acylation / 2.1: deprotonation / 2.2: Alkylation;
DOI:10.1021/jm000004e

Reference yield:

: 2882-15-7
5-Methoxy-2-methylindole-3-acetic acid

: 288854-06-8
[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: BOP-Cl; Et₃N / CH₂Cl₂ / 0.17 h / 20 °C

1.2: 67 percent / CH₂Cl₂ / 20 °C

2.1: NaH / dimethylformamide / 0.33 h / 0 °C

2.2: 73 percent / dimethylformamide

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 1.2: Acylation / 2.1: deprotonation / 2.2: Alkylation;
DOI:10.1021/jm000004e