1-(tert-butoxycarbonyl)-5-[(E)-2-(4-phenyl-5-trifluormethyl-2-thienyl)ethenyl]indoline

Base Information

• Chemical Name: 1-(tert-butoxycarbonyl)-5-[(E)-2-(4-phenyl-5-trifluormethyl-2-thienyl)ethenyl]indoline
• CAS No.: 957204-40-9
• Molecular Formula: C₂₆H₂₄F₃NO₂S
• Molecular Weight: 471.543
• Mol file: 957204-40-9.mol

Synonyms:1-(tert-butoxycarbonyl)-5-[(E)-2-(4-phenyl-5-trifluormethyl-2-thienyl)ethenyl]indoline

Chemical Property of 1-(tert-butoxycarbonyl)-5-[(E)-2-(4-phenyl-5-trifluormethyl-2-thienyl)ethenyl]indoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(tert-butoxycarbonyl)-5-[(E)-2-(4-phenyl-5-trifluormethyl-2-thienyl)ethenyl]indoline

There total 1 articles about 1-(tert-butoxycarbonyl)-5-[(E)-2-(4-phenyl-5-trifluormethyl-2-thienyl)ethenyl]indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 5-formyl-2,3-dihydro-1H-indol-1-carboxylate (879887-32-8) + (4-phenyl-5-trifluormethyl-2-thienyl)methyl phosphonic acid diethyl ester (945984-58-7) → 1-(tert-butoxycarbonyl)-5-[(E)-2-(4-phenyl-5-trifluormethyl-2-thienyl)ethenyl]indoline (957204-40-9)

Guidance literature:

(4-phenyl-5-trifluormethyl-2-thienyl)methyl phosphonic acid diethyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

tert-butyl 5-formyl-2,3-dihydro-1H-indol-1-carboxylate; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

1-(tert-butoxycarbonyl)-5-[(E)-2-(4-phenyl-5-trifluormethyl-2-thienyl)ethenyl]indoline (957204-40-9) → 1-(tert-butoxycarbonyl)-5-[2-(4-phenyl-5-trifluormethyl-2-thienyl)ethyl]indoline (957204-41-0)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethyl acetate; at 20 ℃; for 3h;

upstream raw materials:

tert-butyl 5-formyl-2,3-dihydro-1H-indol-1-carboxylate

(4-phenyl-5-trifluormethyl-2-thienyl)methyl phosphonic acid diethyl ester

Downstream raw materials:

1-(tert-butoxycarbonyl)-5-[2-(4-phenyl-5-trifluormethyl-2-thienyl)ethyl]indoline