(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

Base Information

Chemical Name:(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine
CAS No.:937057-89-1
Molecular Formula:C₂₃H₂₂ClN₅O₃
Molecular Weight:451.912
Hs Code.:

Synonyms:(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

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Chemical Property of (4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

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Technology Process of (4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

There total 13 articles about (4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937057-88-0
3-(5-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}1H-1,2,3,4-tetrazol-1-yl)propanenitrile

: 937057-89-1
(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937057-89-1
(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

Guidance literature:: Multi-step reaction with 12 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 2 h / 50 °C / Heating / reflux

1.3: 0.5 h / Heating / reflux

2.1: toluene / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6.2: 3 h / 0 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

8.1: dimethyl sulfoxide / 13 h / 50 °C

9.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux

9.2: 0 °C

10.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

11.1: trimethylsilylazide; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; trimethylsilylazide; water; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; isopropyl alcohol; trifluoroacetic acid; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene; 11.1: Mitsunobu reaction;

Reference yield:

: 937057-71-1
3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionitrile

: 937057-89-1
(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux

1.2: 0 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3.1: trimethylsilylazide; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

With sodium hydroxide; trimethylsilylazide; water; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; isopropyl alcohol; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; 3.1: Mitsunobu reaction;