1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester

Base Information

• Chemical Name: 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester
• CAS No.: 731857-76-4
• Molecular Formula: C₂₄H₁₃F₁₇O₅S
• Molecular Weight: 736.403
• Mol file: 731857-76-4.mol

Synonyms:1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester

Chemical Property of 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester

There total 1 articles about 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

diethyl 2-(4-methoxyphenyl)-2-oxoethylphosphonate (18276-85-2) + 4-Formylphenyl-perfluoro-1-octanesulfonate → 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester (731857-76-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 25 ℃; for 1h;

DOI:10.1016/j.tetlet.2004.04.115 DOI:10.1016/j.jfluchem.2005.11.006

Reference yield: 63.0%

benzamidin (618-39-3) + 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester (731857-76-4) → 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-octane-1-sulfonic acid 4-[6-(4-methoxy-phenyl)-2-phenyl-pyrimidin-4-yl]-phenyl ester (731857-77-5)

Guidance literature:

With lithium carbonate; In N,N-dimethyl acetamide; at 95 ℃; for 24h;

DOI:10.1016/j.tetlet.2004.04.115 DOI:10.1016/j.jfluchem.2005.11.006

Reference yield:

1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 4-[(E)-3-(4-methoxy-phenyl)-3-oxo-propenyl]-phenyl ester (731857-76-4) → 4-(4-methoxyphenyl)-2,6-bisphenylpyrimidine (67073-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Li₂CO₃ / N,N-dimethyl-acetamide / 24 h / 95 °C

2: 83 percent / HCO₂H; K₂CO₃ / Pd(dppf)Cl₂ / toluene; acetone; H₂O / 0.33 h / 100 °C / microwave irradiation

With formic acid; lithium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl acetamide; water; acetone; toluene;

DOI:10.1016/j.tetlet.2004.04.115

upstream raw materials:

diethyl 2-(4-methoxyphenyl)-2-oxoethylphosphonate

Downstream raw materials:

1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-octane-1-sulfonic acid 4-[6-(4-methoxy-phenyl)-2-phenyl-pyrimidin-4-yl]-phenyl ester

4-(4-methoxyphenyl)-2,6-bisphenylpyrimidine