O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine

Base Information

Chemical Name:O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine
CAS No.:1429504-44-8
Molecular Formula:C₄₅H₅₁N₇O₁₄
Molecular Weight:913.938
Hs Code.:

O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine

Synonyms:O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine

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Chemical Property of O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine

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Technology Process of O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine

There total 7 articles about O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1429504-43-7
C₄₅H₅₁N₇O₁₂

: 1429504-44-8
O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine

Guidance literature:: C₄₅H₅₁N₇O₁₂; With ozone; In dichloromethane; at -78 ℃; for 0.0833333h;

With dimethylsulfide; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/ja4012468

Reference yield:

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 1429504-44-8
O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 8 h / 20 °C

2.1: diethylamine / dichloromethane / 2 h / 20 °C

3.1: imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; sodium hydrogencarbonate / water; methanol / 12 h / 20 °C

4.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

7.1: ozone / dichloromethane / 0.08 h / -78 °C

7.2: 2 h / -78 °C

With imidazole-1-sulfonyl azide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; ozone; acetic acid; diethylamine; N-ethyl-N,N-diisopropylamine; N-methylaniline; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja4012468

Reference yield:

: 1429504-38-0
C₃₈H₅₃N₃O₉Si

: 1429504-44-8
O-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-(N-(tert-butoxycarbonyl)formamido)phenyl)-4-oxobutanoyl)-N-((S)-2-azido-4-(tert-butoxy)-4-oxobutanoyl)-L-threonylglycine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethylamine / dichloromethane / 2 h / 20 °C

2.1: imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; sodium hydrogencarbonate / water; methanol / 12 h / 20 °C

3.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

6.1: ozone / dichloromethane / 0.08 h / -78 °C

6.2: 2 h / -78 °C

With imidazole-1-sulfonyl azide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; ozone; acetic acid; diethylamine; N-ethyl-N,N-diisopropylamine; N-methylaniline; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ja4012468