4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate

Base Information

• Chemical Name: 4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate
• CAS No.: 246047-93-8
• Molecular Formula: C₃₃H₅₁NO₁₁Si₂
• Molecular Weight: 693.939
• Mol file: 246047-93-8.mol

Synonyms:4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate

Chemical Property of 4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate

There total 1 articles about 4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl 4-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)butanoate (176375-43-2) + 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoic acid (246047-92-7) → 4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate (246047-93-8)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In diethyl ether;

DOI:10.1021/jo982477n

Reference yield: 99.0%

4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate (246047-93-8) → 4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 4,5-dihydroxy-3-methoxybenzoate (246047-94-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.0833333h;

DOI:10.1021/jo982477n

Reference yield:

4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate (246047-93-8) → 3,4-dihydroxy-5-methoxybenzoic acid (3934-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / TBAF / tetrahydrofuran / 0.08 h

2: 55 percent / tetrahydrofuran; ethanol; H₂O / Irradiation

With tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol; water; 1: Substitution / 2: Substitution;

DOI:10.1021/jo982477n

upstream raw materials:

methyl 4-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)butanoate

3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoic acid

Downstream raw materials:

4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 4,5-dihydroxy-3-methoxybenzoate

3,4-dihydroxy-5-methoxybenzoic acid

4-methoxybenzyl 3-methoxy-1,2-dioxocyclohexa-3,5-diene-5-carbohydrate

3,4-dihydroxy-5-methoxy-benzoic acid 4-methoxy-benzyl ester