176375-43-2

Upstream product

• 4897-84-1 Methyl 4-bromobutyrate 
• 2454-72-0 6-nitrovanillin 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 260417-00-3 4-(hydroxymethyl)-2-methoxy-5-nitrophenol 
• 121-33-5 vanillin 
• 176375-41-0 4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester 
• 3153-37-5 methyl 4-chlorobutyrate 
• 176375-42-1 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid methyl ester 

Downstream Products

• 246047-93-8 4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 3,4-bis(tert-butyldimethylsiloxy)-5-methoxybenzoate 
• 1402231-61-1 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoic acid 
• 355017-64-0 4-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 
• 176375-46-5 4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester 
• 176375-45-4 4-(4-{5-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-pentylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester 
• 176375-52-3 4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid 
• 176375-44-3 4-(4-{4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-butylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester 
• 176375-51-2 4-(4-{5-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-pentylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid 
• 176375-50-1 4-(4-{4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-butylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid 
• 176375-55-6 4-[4-(6-Hydroxy-hexylcarbamoyloxymethyl)-2-methoxy-5-nitro-phenoxy]-butyric acid methyl ester 
• 176375-54-5 4-[4-(5-Hydroxy-pentylcarbamoyloxymethyl)-2-methoxy-5-nitro-phenoxy]-butyric acid methyl ester 
• 176375-53-4 4-[4-(4-Hydroxy-butylcarbamoyloxymethyl)-2-methoxy-5-nitro-phenoxy]-butyric acid methyl ester 
• 246047-94-9 4-(3-(carbomethoxy)propoxy)-5-methoxy-2-nitrobenzyl 4,5-dihydroxy-3-methoxybenzoate 
• 1402231-71-3 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)-N-(3-(triethoxysilyl)propyl)butanamide 

Relevant academic research and scientific papers

Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

Here we report the use of 2-nitrobenzyl alcohol (NB) as a photoreactive group with amine selectivity and explore its applications for photoaffinity labeling and crosslinking of biomolecules. This work confirms that NB is an efficient photoreactive group a

Photoresponsive multifunctional chemical crosslinking agent and preparation method and application thereof

The invention discloses a photoresponsive multifunctional chemical crosslinking agent. The structure of the crosslinking agent is shown in a formula I, wherein the definition of each substituent groupin the formula I is shown in the description. The prepa

(Bio)molecular surface patterning by phototriggered oxime ligation

Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces (see scheme) with a fluoro marker and GRGSGR peptide, and can be imaged by time-of-flight secondary-ion mass spectrometry. Copyright

SYNTHESIS OF PROTECTED PYRROLOBENZODIAZEPINES

A method of synthesis of a N-10 protected PBD compound of formula (I) via an intermediate of formula (II) or formula (V).

Substituted stilbenes and their reactions

The present invention relates to stilbene and quinone compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis or trans-stilbenes, compounds with one or more (and preferably 2 or 3) alkyl group substituents on the stilbene A ring, compounds with an alkoxy group other than methoxy at position 3, 4, and/or 5 of the stilbene A ring, compounds (or prodrugs) in which BOC amino acid esters are formed with the phenolic hydroxyl at the 3-position of the B ring and compounds (or prodrugs) based on a benzoquinone B ring. The present invention further relates to the photochemical reactions of stilbene compounds, either the above compounds disclosed for the first time herein or compounds based on prior art stilbenes. These reactions include the photochemical release of an active form of the compound from a prodrug conjugate and the photochemical isomerisation of the compounds, especially from a trans to cis form of compounds. The reactions can be used alone or in combination to convert inactive or comparatively less active forms of the compounds to more active forms, thereby allowing the compounds to be selectively targeted, e.g. activating them at the site of a tumour.

Novel solid phase synthesis supports for the preparation of oligonucleotides containing 3'-alkyl amines

The synthesis and application of photolabile supports for solid phase oligonucleotide synthesis that release oligonucleotides containing 3'-alkyl amines is described. The alkyl amine functionality can be revealed without removing any other protecting groups throughout the biopolymer. The solid phase synthesis supports do not contain a nucleoside, making it possible to use a single support for the synthesis of oligonucleotides independent of their sequence. Individual solid phase synthesis supports differ according to the length of the alkyl tether between the 4,4'-dimethoxytrityl group which serves as the initiation site for oligonucleotide synthesis and the latent alkyl amine. Eicosameric oligonucleotides are obtained in yields ranging from 70-98% under photolysis conditions that are known to produce less than 3% thymidine·thymidine photodimers. Longer oligonucleotides (30 and 40 nucleotides in length) are cleaved from these solid phase synthesis supports in lower yields.