(R_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate)

Base Information

• Chemical Name: (R_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate)
• CAS No.: 160971-74-4
• Molecular Formula: C₃₉H₄₀N₃O₈PSe
• Molecular Weight: 788.696

Synonyms:(R_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate)

Chemical Property of (R_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate)

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (R_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate)

There total 3 articles about (R_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → (RP)-5'-O-dimethoxytrityl-N4-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate) (160971-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Et₃N, 2.) Se / 1.) THF, -40 deg C, 1 h, 2.) room temperature, overnight

2: 1.) NaH, CO₂ / 1.) DMF, 4 h

With selenium; carbon dioxide; sodium hydride; triethylamine;

DOI:10.1021/jo980225g

Reference yield:

C38H38N3O8PSe + methyl iodide (74-88-4) → (SP)-5'-O-dimethoxytrityl-N4-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate) (160971-75-5) + (RP)-5'-O-dimethoxytrityl-N4-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate) (160971-74-4)

Guidance literature:

In dichloromethane;

DOI:10.1021/jo00099a001

Reference yield:

(RP)-5'-O-dimethoxytrityl-N4-benzoylcytidine 3'-O-methanephosphonoselenoanilidate + methyl iodide (74-88-4) → (RP)-5'-O-dimethoxytrityl-N4-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate) (160971-74-4)

Guidance literature:

With carbon dioxide; sodium hydride; Yield given. Multistep reaction; 1.) DMF, 4 h;

DOI:10.1021/jo980225g

upstream raw materials:

methyl iodide

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

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