1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione
• CAS No.: 1340544-59-3
• Molecular Formula: C₁₇H₁₉N₃O₅S
• Molecular Weight: 377.421

Synonyms:1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

Chemical Property of 1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

Chemical Property:

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Technology Process of 1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

There total 2 articles about 1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1,2,3,4-tetrahydro-2-(2-hydroxyethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-57-1) + methanesulfonyl chloride (124-63-0) → 1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-59-3)

Guidance literature:

With pyridine; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2011.08.006

Reference yield:

2,5-dimethyl-1-phenyl-3,4-pyrroledicarboxylic acid anhydride (158576-66-0) → 1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 7 h / Reflux

2: pyridine / 6 h / 20 °C

With pyridine; In acetonitrile;

DOI:10.1016/j.ejmech.2011.08.006

Reference yield: 69.0%

1,2,3,4-tetrahydro-2-[2-(mesyloxy)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-59-3) + 1-(o-fluorophenyl)piperazine (1011-15-0) → C26H28FN5O2 (1340544-44-6)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 16h; Reflux;

DOI:10.1016/j.ejmech.2011.08.006

upstream raw materials:

1,2,3,4-tetrahydro-2-(2-hydroxyethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

methanesulfonyl chloride

2,5-dimethyl-1-phenyl-3,4-pyrroledicarboxylic acid anhydride

Downstream raw materials:

1,2,3,4-tetrahydro-2-[2-(4-phenylpiperazin-1-yl)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

C₂₈H₃₂N₄O₂

C₂₅H₂₈N₆O₂

C₂₇H₃₁N₅O₂

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