3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid

Base Information

Chemical Name:3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid
CAS No.:632624-93-2
Molecular Formula:C₂₆H₂₀ClF₂NO₄
Molecular Weight:483.899
Hs Code.:

Synonyms:3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid

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Chemical Property of 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid

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Technology Process of 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid

There total 7 articles about 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-difluoromethoxybenzoic acid methyl ester

: 632624-93-2
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid

Guidance literature:: With sodium hydroxide; water; In ethanol; for 2h; Heating / reflux;

Reference yield:

: 632626-83-6
2-difluoromethoxy-5-nitro-benzoic acid methyl ester

: 632624-93-2
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 5%-palladium/activated carbon / methanol / 6 h / 20 °C / 760.05 Torr

2: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 0.17 h / 150 °C / Microwave

3: sodium hydroxide; water / ethanol / 2 h / Heating / reflux

With sodium hydroxide; water; hydrogen; 5%-palladium/activated carbon; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; methanol; ethanol;

Reference yield:

: 38544-16-0
2-(benzyloxy)-5-chlorobenzaldehyde

: 632624-93-2
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

2: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 0.17 h / 150 °C / Microwave

3: sodium hydroxide; water / ethanol / 2 h / Heating / reflux

With sodium hydroxide; water; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; ethanol;