2-(Benzyloxy)-5-chlorobenzaldehyde

Base Information

• Chemical Name: 2-(Benzyloxy)-5-chlorobenzaldehyde
• CAS No.: 38544-16-0
• Molecular Formula: C14H11 Cl O2
• Molecular Weight: 246.693
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID40358375
• Nikkaji Number: J1.863.215B
• Wikidata: Q82138892
• Mol file: 38544-16-0.mol

Synonyms:2-(benzyloxy)-5-chlorobenzaldehyde;38544-16-0;5-chloro-2-phenylmethoxybenzaldehyde;5-chloro-2-(phenylmethoxy)benzaldehyde;SCHEMBL1119150;DTXSID40358375;5-chloro-2-benzyloxy-benzaldehyde;UKVVPQTUCJPTNI-UHFFFAOYSA-N;2-Benzyloxy-5-chloro-benzaldehyde;BBL014014;MFCD03422424;STK027467;AKOS000290598;VS-04112;5-chloro-2-[(phenylmethyl)oxy]benzaldehyde;CS-0190927;FT-0730037;EN300-92332;E83835;SR-01000262639;A1-00458;SR-01000262639-1;Z57773199

Chemical Property of 2-(Benzyloxy)-5-chlorobenzaldehyde

Chemical Property:

• Vapor Pressure: 3.95E-06mmHg at 25°C
• Melting Point: 70-72 °C(Solv: hexane (110-54-3))
• Refractive Index: 1.615
• Boiling Point: 384.9°C at 760 mmHg
• Flash Point: 160°C
• PSA: 26.30000
• Density: 1.247g/cm³
• LogP: 3.73150
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 246.0447573
• Heavy Atom Count: 17
• Complexity: 238

Purity/Quality:

97% ^*data from raw suppliers

2-(Benzyloxy)-5-chlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=C(C=C(C=C2)Cl)C=O

Technology Process of 2-(Benzyloxy)-5-chlorobenzaldehyde

There total 5 articles about 2-(Benzyloxy)-5-chlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl bromide (100-39-0) + 5-chlorosalicyclaldehyde (635-93-8) → 2-(benzyloxy)-5-chlorobenzaldehyde (38544-16-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.bmcl.2006.12.021

Reference yield: 85.0%

benzyl chloride (100-44-7) + 5-chlorosalicyclaldehyde (635-93-8) → 2-(benzyloxy)-5-chlorobenzaldehyde (38544-16-0)

Guidance literature:

With potassium carbonate; potassium iodide; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/j.bmc.2004.12.026

Reference yield:

salicylaldehyde (90-02-8) → 2-(benzyloxy)-5-chlorobenzaldehyde (38544-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorine; acetic acid / 1.5 h / 20 °C

2: potassium hydroxide / ethanol / 2 h / Reflux

With chlorine; acetic acid; potassium hydroxide; In ethanol;

DOI:10.1039/c3ra41325j

upstream raw materials:

benzyl chloride

5-chlorosalicyclaldehyde

benzyl bromide

salicylaldehyde

Downstream raw materials:

3-(2-benzyloxy-5-chlorophenyl)-3-hydroxy-2-methylenepropanenitrile

1-[5-chloro-2-(benzyloxy)phenyl]-hexane-1,4-dione

methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

1-(2-benzyloxy-5-chloro-benzyl)-5-methyl-1H-pyrazol-3-ol