N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide

Base Information

Chemical Name:N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide
CAS No.:509093-72-5
Molecular Formula:C₂₇H₂₅F₃N₄O
Molecular Weight:478.517
Hs Code.:

Synonyms:N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide

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Chemical Property of N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide

Chemical Property:

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Technology Process of N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide

There total 6 articles about N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 509093-72-5
N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

2: N-ethyl-N,N-diisopropylamine / 150 °C

3: tin(II) chloride dihdyrate / ethanol; ethyl acetate / Reflux

4: acetonitrile; methanol; water

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide

With 4-methyl-morpholine; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2015.10.060

Reference yield:

: 509093-76-9
1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-ylamine

: 454-92-2
3-(trifluoromethyl)benzoic acid

: 509093-72-5
N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 509093-72-5
N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; dichloromethane

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

3: N-ethyl-N,N-diisopropylamine / 150 °C

4: tin(II) chloride dihdyrate / ethanol; ethyl acetate / Reflux

5: acetonitrile; methanol; water

6: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide

With 4-methyl-morpholine; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium bromide; In methanol; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2015.10.060