9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione

Base Information

Chemical Name:9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione
CAS No.:130475-28-4
Molecular Formula:C₂₃H₂₈N₄O₄S
Molecular Weight:456.566
Hs Code.:

Synonyms:9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione

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Chemical Property of 9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione

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Technology Process of 9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione

There total 6 articles about 9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 130475-22-8
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

: 130475-28-4
9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione

Guidance literature:: With sodium tetrahydroborate; In ethanol; Ambient temperature;

Reference yield:

: 39978-14-8
methyl 3-amino-4-thiophenecarboxylate hydrochloride

: 130475-28-4
9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

3: 1.) NaH / 1.) DMF, 30 min, r.t., 2.) 16 h, r.t.

4: 70 percent / 50percent aq. NaOH / methanol / Heating

5: 70 percent / P₂O₅, CH₃SO₃H (1:10) / Ambient temperature

6: 92 percent / NaBH₄ / ethanol / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; methanesulfonic acid; trimethylaluminum; phosphorus pentoxide; sodium hydride; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 118252-16-7
ethyl (4-methoxycarbonyl)thiophene-3-carbamate

: 130475-28-4
9-Hydroxy-4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-benzo[cd]azulene-3,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

2: 1.) NaH / 1.) DMF, 30 min, r.t., 2.) 16 h, r.t.

3: 70 percent / 50percent aq. NaOH / methanol / Heating

4: 70 percent / P₂O₅, CH₃SO₃H (1:10) / Ambient temperature

5: 92 percent / NaBH₄ / ethanol / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; methanesulfonic acid; trimethylaluminum; phosphorus pentoxide; sodium hydride; In methanol; ethanol; toluene;