4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

Base Information

Chemical Name:4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione
CAS No.:130475-22-8
Molecular Formula:C₂₃H₂₆N₄O₄S
Molecular Weight:454.55
Hs Code.:

Synonyms:4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

Suppliers and Price of 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

There total 5 articles about 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 130475-83-1
4-(3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-thieno[3,4-d]pyrimidin-1-yl)-butyric acid

: 130475-22-8
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

Guidance literature:: With methanesulfonic acid; phosphorus pentoxide; Ambient temperature;

Reference yield:

: 39978-14-8
methyl 3-amino-4-thiophenecarboxylate hydrochloride

: 130475-22-8
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

3: 1.) NaH / 1.) DMF, 30 min, r.t., 2.) 16 h, r.t.

4: 70 percent / 50percent aq. NaOH / methanol / Heating

5: 70 percent / P₂O₅, CH₃SO₃H (1:10) / Ambient temperature

With sodium hydroxide; methanesulfonic acid; trimethylaluminum; phosphorus pentoxide; sodium hydride; In methanol; dichloromethane; toluene;

Reference yield:

: 118252-16-7
ethyl (4-methoxycarbonyl)thiophene-3-carbamate

: 130475-22-8
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

2: 1.) NaH / 1.) DMF, 30 min, r.t., 2.) 16 h, r.t.

3: 70 percent / 50percent aq. NaOH / methanol / Heating

4: 70 percent / P₂O₅, CH₃SO₃H (1:10) / Ambient temperature

With sodium hydroxide; methanesulfonic acid; trimethylaluminum; phosphorus pentoxide; sodium hydride; In methanol; toluene;