6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole
• CAS No.: 1476847-54-7
• Molecular Formula: C₂₀H₁₄BrN₃O₃S
• Molecular Weight: 456.319

Synonyms:6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole

Chemical Property of 6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole

Chemical Property:

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Technology Process of 6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole

There total 18 articles about 6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone (1476847-52-5) + 5-bromo-2-amino-1,3,4-thiadiazole (37566-39-5) → 6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole (1476847-54-7)

Guidance literature:

In isopropyl alcohol; at 78 - 150 ℃; for 18.5h; Microwave irradiation;

Reference yield: 64.0%

1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone (1476847-52-5) + 5-bromo-2-amino-1,3,4-thiadiazole (37566-39-5) → 1-[4-(benzyloxy)-6-methoxy-1-benzofuran-2-yl]ethan-1-one (1476847-51-4) + 6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole (1476847-54-7)

Guidance literature:

In isopropyl alcohol;

Reference yield: 33.0%

1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-chloroethanone + 5-bromo-2-amino-1,3,4-thiadiazole (37566-39-5) → 6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazole (1476847-54-7)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 80 - 120 ℃; for 11h; Inert atmosphere;

upstream raw materials:

1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

5-bromo-2-amino-1,3,4-thiadiazole

benzyl bromide

5-(benzyloxy)-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3 ]dioxin-4-one

Downstream raw materials:

2-Methoxy-6-(6-methoxy-4-((5-phenyl-1,3,4-thiadiazol-2-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

2-Methoxy-6-(6-methoxy-4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

2-Methoxy-6-(6-methoxy-4-((1-phenyl-1H-1,2,3-triazol-5-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

6-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole

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